By Randall Roland, D.O.

Have you ever stood up and suddenly felt dizzy, lightheaded, weak, or like you might pass out?
That can happen when your blood pressure drops too much when you change positions, especially when going from sitting or lying down to standing. This is called orthostatic hypotension.
In plain English: Your blood pressure falls when you stand up, and your brain may not get enough blood for a few seconds.
You may feel:
This can be dangerous because it may lead to falls, especially in older adults.
When you stand up, gravity pulls blood down toward your legs. Normally, your body quickly tightens your blood vessels and speeds up your heart a little to keep blood flowing to your brain.
Some medicines can interfere with that process.
They may:
Examples include:
These medicines help your body get rid of extra fluid. That can be helpful for blood pressure, heart failure, or swelling.
But sometimes they can remove too much fluid, leaving you dehydrated or with less blood volume. Less fluid in the body can mean lower blood pressure when standing.
Examples include:
These medicines relax muscles around the prostate and bladder to help with urination. But they can also relax blood vessels, which may drop blood pressure, especially when standing up.
Some blood pressure medicines can contribute to dizziness when standing.
Examples include:
These medicines can be very important and should not be stopped suddenly. But in some people, the dose may be too strong, or the combination of medicines may lower blood pressure too much.
Examples include:
These medicines relax blood vessels. That can lower blood pressure.
A special warning: Do not mix nitroglycerin with sildenafil or tadalafil unless your doctor specifically says it is safe. This combination can cause a dangerous blood pressure drop.
Examples include:
Some antidepressants and sleep medicines can make it harder for your body to control blood pressure when you stand. They may also cause sleepiness, which increases fall risk.
Examples include:
These medicines can relax blood vessels and affect the nervous system. Dizziness when standing can happen, especially when starting the medicine or increasing the dose.
Examples include:
These medicines help remove sugar through the urine. They can also make you urinate more, which may lower body fluid levels and contribute to dehydration or dizziness.
Try these steps:
Call your doctor if:
Get urgent medical care if dizziness comes with:
Even if you think a medicine is causing dizziness, do not stop it suddenly without talking to your doctor. Some medicines can cause serious problems if stopped too fast.
Instead, bring your medicine list to your visit. Your doctor may adjust the dose, change the timing, switch medications, or check for dehydration or other causes.
Dizziness when standing is common, but it should not be ignored. Many medicines can contribute to it, especially water pills, blood pressure medicines, prostate medicines, antidepressants, antipsychotics, nitroglycerin-type medicines, and some diabetes medicines.
The goal is not to blame the medicine. The goal is to find the safest balance so you can treat your health problems without increasing your risk of falls or fainting.
This content is provided for educational and informational purposes only and does not constitute medical advice, diagnosis, or treatment. Reading this article does not establish a physician-patient relationship. Treatment decisions should always be made in consultation with a qualified licensed healthcare professional. If you are experiencing a medical emergency, call 911 immediately.
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